The new chemical entities (NCE’s) discovered by medicinal chemist have good pharmacological action but have poor pharmacokinetic properties. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Hence, enhancement of solubility becomes prime requisite for formulation scientist. Various methods are used for enhancement of solubility. The current review enlists various methods for enhancement for solubility with special emphasis on Solid dispersion. It focuses on in detail on methods of preparation, evaluation, types of carriers and applications of solid dispersion.
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